The cytoplasmic RNA of HeLa cells: new discrete species associated with mitochondria.
نویسندگان
چکیده
Two new species of cytoplasmic RNA with approximate sedimentation values of 12S and 21S, and which appear associated with mitochondria, are described. The species are unmethylated, are relatively metabolically stable, and have a 43 per cent G + C content. Their synthesis is uniquely resistant to inhibition by UV irradiation. The 12S and 21S RNA do not appear to be components of polysome-like structures.
منابع مشابه
Differences in the methylation of transfer ribonucleic acid in vitro by the mitochondrial and cytoplasmic transfer ribonucleic acid methylases of HeLa cells.
The methylation of Escherichia coli B transfer RNA in vitro by HeLa mitochondrial and cytoplasmic extracts was examined. The following differences were found. (a) The cytoplasmic extract methylated E. coli B tRNA to a much greater extent than did the mitochondrial extract. (b) The two extracts methylated different sites on E. coli B tRNA, thereby generating different methylated oligonucleotide ...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 62 1 شماره
صفحات -
تاریخ انتشار 1969